PECAM-1

This MAb to human endothelial cell surface markers interacts with M_r-135,000 PECAM-1 polypeptides from leukocytes and endothelial cells. It can also detect all breast endothelial cells, and identifies erythroid differentiation in human leukemic cells. It can be used in immunohistochemical staining, western blotting and other immunoassays for cellular and tumour biology. Ulex Europaeus-agglutinin-I reactive glycoproteins – taken from cultured human umbilical vein endothelial cells – were isolated by lecithin-affinity chromatography and used as immunogens for antibody production.