Detecting H. pylori as a cause of upper abdominal symptoms
Helicobacter pylori (H. pylori) infection is an independent risk factor for gastric cancer and peptic ulcer disease. This spiral shaped gram-negative bacterium is also the most critical cause of chronic gastritis which leads to atrophy of the gastric mucosa. The BIOHIT H. pylori IgG ELISA is for the quantitative detection of human IgG class antibodies to H. pylori in EDTA plasma. The test is intended for diagnosis of H. pylori infection in adult patients with upper abdominal symptoms (e.g. dyspepsia).
H. pylori-associated atrophic gastritis
H. pylori IgG antibodies give significant added diagnostic value to the three other GastroPanel biomarkers (pepsinogen I, pepsinogen II and gastrin-17), indicating two potentially different conditions – either an ongoing H. pylori infection or a previous exposure to the bacterium. When H. pylori IgG is the only abnormal marker, this suggests an H. pylori -associated superficial gastritis (non-atrophic gastritis). When a raised antibody level is combined with abnormalities in the other three GastroPanel markers, this confirms the diagnosis of H. pylori -associated atrophic gastritis (antrum or corpus).
BIOHIT’s series of unified kits feature methods that have been standardised across all analytes and optimised for automation.
This assay is part of the BIOHIT GastroPanel product.
