Zonulin

Zonulin is a protein that regulates the permeability of tight junctions between cells in the gut lining. Tight junctions are essential for maintaining the integrity of the intestinal barrier, controlling the passage of molecules and ions between the gut lumen and the bloodstream. Zonulin plays a key role in modulating the opening and closing of these tight junctions, thereby regulating the permeability of the intestinal barrier. Dysregulation of zonulin levels or function has been implicated in various gastrointestinal disorders, including inflammatory bowel disease (IBD), celiac disease, and leaky gut syndrome. Increased zonulin levels can lead to increased intestinal permeability, allowing for the passage of larger molecules, toxins, and pathogens into the bloodstream, which may trigger an immune response and contribute to the development or exacerbation of gastrointestinal inflammation and other related conditions. Understanding the role of zonulin in gut health is crucial for identifying potential therapeutic targets and interventions aimed at restoring intestinal barrier function and mitigating the symptoms of gastrointestinal disorders.