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Vitronectin

This MAb is specific to human tissue extracellular matrix components such as vitronectin, with no cross-reaction with other matrix molecules. It can be used in immunohistochemical staining, immunoblotting and other immunoassays for cellular and tumour biology research. Purified vitronectin from human plasma is used as an immunogen for antibody production.

Vinculin

This human cytoskeletal polypeptide MAb can be used in immunoblotting, immunohistochemical staining and other immunoassays for cellular and tumour biology research. In immunoblotting, it identifies a 130 kD polypeptide. Vinculin, purified from human smooth muscle tissue, is used as an immunogen for antibody production.

Vimentin

This human cytoskeletal polypeptide MAb recognises vimentin with an Mr of 57,000 in mesenchymal cells, and can be used in immunohistochemical staining and western blotting. Purified vimentin, obtained via electrophoresis from cultured human fibroblasts, is used as an immunogen for antibody production.

Tenascin-C – IgG1, clone EB2

This human extracellular MAb interacts with the fourth and fifth fibronectin-like repeats of human tenascin-C polypeptides with an Mr of 250,000 and 180,000. It can cross-react with humans, guinea pigs and rabbits. It can also be used in immunohistochemical staining, western blotting and other immunoassays for cellular and tumour biology research, as well as for quantitation of Tenascin-C in body fluids. Purified tenascin-C from human fetal fibroblasts is used as an immunogen for antibody production.

Tenascin-C – IgG2a, clone DB7

This MAb identifies the Mr-250,000 and Mr-180,000 human tenascin polypeptides in immunoprecipitation, or just the Mr-250,000 polypeptide in immunoblots. It can also interact with the fibrinogen-like knob domain of the tenascin protein, especially in paraffin sections of human tissue. It can be used in immunofluorescence, immunoblotting and immunohistochemistry on formalin-fixed or paraffin-embedded sections. Tenascin polypeptides isolated from the spent culture supernatant of human fibroblasts by affinity chromatography are used as immunogens for antibody production.

Plasma fibronectin

This MAb interacts with both cellular and plasma forms of fibronectin, and has an affinity for cellular binding regions. It can cross-react with humans and guinea pigs. This antibody can be used in immunohistochemical staining, western blotting, and other immunoassay methods for cellular and tumour biology. Purified fibronectin from A8387 fibrosarcoma cells is used as an immunogen for antibody production.

Pepsinogen II

This human gastric biomarker MAb is specific to human pepsinogen II, with no cross-reactivity to human pepsinogen I. It is suitable for immunohistochemical staining, western blotting and enzyme immunoassays. Pepsinogen II – purified from human tissue – is used as an immunogen for antibody production.

Pepsinogen I

This human gastric biomarker MAb is specific to human pepsinogen I, with no cross-reactivity to human pepsinogen II. It is suitable for immunohistochemical staining, western blotting and enzyme immunoassays. Pepsinogen I – purified from human tissue – is used as an immunogen for antibody production.

PECAM-1

This MAb to human endothelial cell surface markers interacts with Mr-135,000 PECAM-1 polypeptides from leukocytes and endothelial cells. It can also detect all breast endothelial cells, and identifies erythroid differentiation in human leukemic cells. It can be used in immunohistochemical staining, western blotting and other immunoassays for cellular and tumour biology. Ulex Europaeus-agglutinin-I reactive glycoproteins – taken from cultured human umbilical vein endothelial cells – were isolated by lecithin-affinity chromatography and used as immunogens for antibody production.

Neurofilaments 70, 200

This human cytoskeletal polypeptide MAb interacts with Mr-68,000 and Mr-200,000 neurofilament proteins in human tissues. It can be used in immunohistochemical staining and western blotting. Purified neurofilament triplet proteins from the human spinal cord are used as immunogens for antibody production.

Neurofilaments 150, 200

This cytoskeletal polypeptide MAb interacts with all three neurofilament protein molecules – Mr 68,000, Mr-150,000 and Mr-200,000 – in mice, as well as Mr-150,000 and Mr-200,000 in human tissues. It can be used in immunohistochemical staining and western blotting. Purified neurofilament triplet proteins from human spinal cords were used as immunogens to produce this MAb.

Laminin – gamma 1-chain

This MAb interacts with the Mr-200,000 γ1-chain of human-reduced and alkylated laminin; a protein synthesised by cultured cells. The specificity of this antibody was confirmed by immunoprecipitation and ELISA, using a recombinant γ1-chain. It only reacts with human cells and tissues and, although it does not work in western blotting, it can be used in immunohistochemical staining and immunoprecipitation. Pepsin-digested laminins from human placenta are used as immunogens for antibody production.

Laminin – beta 1-chain

This MAb interacts with the NH2-terminus of the β1-chain subunit of laminin with a molecular mass (Mr) of 220,000. It can be used in human tissues for immunohistochemical staining, immunoblotting and other immunoassays for cellular or tumour biology. This clone reacts strongly both under reducing and non reducing conditions. It can also be successfully used to purify laminin-8 and laminin-10 using affinity chromatography, unlike many other antibodies to the laminin β1-chain. Partially pepsin-digested laminins from human placenta are used as immunogens for antibody production.

Genistein

This MAb recognises and interacts with human genistein. There is some cross-reactivity with daidzein (3.3 %), dihydrodaidzein (2.5 %), dihydrogenistein (0.4 %), and glycitein (0.3 %), but none with equol or O-DMA. It can be used for enzyme or fluorescent immunoassays, and is produced using BSA-conjugated human genistein as an immunogen.

Gastrin-17

This MAb is specific to the human gastric biomarker protein hormone gastrin-17, though it has no cross-reactivity to gastrin-34 or cholecystokinin. It can be used in immunohistochemical staining and enzyme immunoassays. Synthetic gastrin-17 coupled to thyroglobulin is used as an immunogen for antibody production.

Gamma-aminobutyric acid (GABA)

This MAb is highly specific to the human neurotransmitter, GABA, with a weak interaction against the β-alanine BSA-conjugate antigen, but only at the highest concentrations. There is no interaction with any other amino acid-BSA conjugates. It can be used in fluorescence microscopy and other immunohistochemical methods, as well as on frozen sections, provided they have been perfusion fixed beforehand. Glutaraldehyde must be included in the fixative of paraffin sections, if they are used. GABA coupled to BSA with glutaraldehyde is used as an immunogen for antibody production.

Erythroid beta-spectrin

This MAb is specific to the 220 kD human erythroid -spectrin protein, present in skeletal muscle cell membranes. It can be used to identify erythroid leukaemia, to monitor the integrity of muscle cell plasma membranes, and in various immunochemical reactions, immunoprecipitation, western blotting, as well as immunocytochemistry methodologies. Ghost proteins from human red blood cells are used as immunogens for production of this antibody.

Erythroid alpha-spectrin

This MAb is specific to the 240 kD human erythroid α-spectrin protein. It can be used to detect erythroid spectrin or to identify erythroid leukaemia, and also in various immunochemical reactions, immunoprecipitation, western blotting, as well as immunocytochemistry methodologies. Ghost proteins from human red blood cells are used as immunogens for production of this antibody.

Showing 1–18 of 29 results

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